The Bulldogs played their home games at Dudy Noble Field, Polk–DeMent Stadium.

[2] The SEC coaches poll[3] was released on February 11, 2021 with Mississippi State predicted to finish second in the Western Division, receiving three out of fourteen Western Division first place votes.

[4] 2.2 Game versus Jacksonville State was called after 5 innings due to inclement weather.

[16] Before any draftees are signed by their major league team, Mississippi State was ranked 9th in the nation by Perfect Game.

After all players, that were going to, have signed contracts with their major league team, this recruiting class is ranked 16th in the nation.