Floods from these rains affected the area for several days afterwards, resulting in a number of deaths and widespread property damage.

[3] The Cumberland River crested at 51.86 feet (15.81 m) in Nashville, a level not seen since 1937, which was before the U.S. Army Corps of Engineers flood control measures were in place.

A stalled frontal boundary coupled with very moist air streaming northward from the Gulf set the stage for repeated rounds of heavy rainfall.

In addition to the heavy rain, moist air and ample instability contributed to the generation of multiple tornadoes affecting the same areas, which killed five people: four in Mississippi during the early hours of May 2, and one in Arkansas during the evening of April 30.

Flooding on the Cumberland River damaged the Grand Ole Opry House, Gaylord Opryland Resort & Convention Center, Opry Mills, Bridgestone Arena[14] (home to NHL team Nashville Predators), and LP Field (home to NFL team Tennessee Titans) with several feet of water.

The basement flooded in Schermerhorn Symphony Center, causing the destruction of two Steinway grand concert pianos and one organ valued at $2.5 million.

The studios of WSM radio, located inside the Gaylord Opryland Hotel, escaped flooding, but became inaccessible during the restoration of the building.

[17] WSM's administrative offices next to the Grand Ole Opry House were also completely destroyed and later demolished, resulting in the loss of several priceless documents from the station's history.

[16] 40 feet (12 m) of water filled the underground parking garage of The Pinnacle at Symphony Place, a 417-foot (127 m) tower in downtown that opened in February 2010, less than three months before the flood.

[16] In the early morning of May 4, flooding at a Nashville Electric Service substation caused power to go out in the center of the city.

[20] The Dry Creek wastewater treatment plant in Madison was flooded with some equipment areas under more than 40 ft of water.

[22] The Duck River at Centerville exceeded its record level by almost 10 feet flooding or destroying homes, roads, and agricultural land.

The River Fund was created with proceeds from Garth Brooks' December 2010 concerts for flood relief and served the 52 flood-affected counties in Tennessee.

On June 22, 2010, a benefit concert called "Nashville Rising" was held at Bridgestone Arena to raise money for Middle Tennessee flood relief efforts.