All 16 events of the 2010 UCI ProTour were included in the series calendar, along with the three Grand Tours, two early season stage races, and five one-day classics.

[1] †: Riders promoted after removal of the results of Alejandro Valverde or (in the Tour de France) of Alberto Contador Source:[4] On 31 May, the UCI annulled all results obtained by then rankings leader Alejandro Valverde, and removed his points, as he received a suspension due to his involvement in the Operación Puerto doping case.

His points were also removed from his team, Caisse d'Epargne, and the Spanish national score, both of which had previously been at the top of their rankings.

In February 2012, Alberto Contador had all his results from the 2010 Tour de France annulled, and these points were retrospectively reallocated in the 2010 rankings.

The top ten nations as of 15 August were permitted up to nine riders at the 2010 UCI Road World Championships in Australia in October.