Massachusetts has ten seats in the House, apportioned according to the 2000 United States census.

The Republican Party nominee is Tom Wesley, who defeated Jay Fleitman in the September primary.

Massachusetts's 4th congressional district lies in the southern part of the state, including the South Coast region.

It has been represented by Democrat Niki Tsongas since she won a special election on October 16, 2007, upon the resignation of Marty Meehan (D).

Massachusetts's 7th congressional district lies in the eastern part of the state, including some Boston suburbs.

In response to Lynch's vote against health care reform, Needham selectwoman Harmony Wu announced she was considering a run against Lynch in the Democratic Primary, but announced on April 7, 2010, that she decided not to run.

On April 22 Mac D'Alessandro,[11] the New England political director of SEIU, announced his intention to challenge Lynch.

Democrat Bill Delahunt, who has represented the seat since 1997, announced in March 2010 that he did not plan to run for re-election.

[14] Joseph P. Kennedy III was considered a likely Democratic contender, but he chose not to run.

[15] It was reported in the Boston Globe, that District Attorney of Norfolk County William R. Keating also sought the Democratic nomination for the seat.

[19] Despite a movement to draft him into running, Republican State Senator Bob Hedlund decided not to enter this race.