Despite a 1-6 start the Cardinals managed to win 7 out of 9 games, including a stunning upset against the San Francisco 49ers in week 14.

Despite the Cardinals holding a 10-point lead twice in the fourth quarter, the Giants scored three touchdowns in the final frame as Arizona dropped its third straight game and fell to 1–3.

Arizona trailed early in the first quarter as Steelers quarterback Ben Roethlisberger completed a 12-yard touchdown pass to tight end Heath Miller.

Pittsburgh would add onto their lead in the second quarter as Roethlisberger completed a 95-yard touchdown pass to wide receiver Mike Wallace.

Arizona opened the third quarter with quarterback Kevin Kolb finding running back LaRod Stephens-Howling on a 73-yard touchdown pass, but Pittsburgh struck back with Roethlisberger completing a 4-yard touchdown pass to wide receiver Emmanuel Sanders, along with Kolb's intentional grounding penalty in the endzone resulting in a safety.

The Cardinals tried to rally as Kolb found wide receiver Early Doucet on a 2-yard touchdown pass (with a failed two-point conversion), but Pittsburgh held on to preserve the victory.

The Cardinals snapped their six-game losing streak as rookie Patrick Peterson returned a punt 98 yards for a game-winning touchdown in overtime.

Whisenhunt was the all-time leader in wins for Cardinals head coaches until his record was broken by Bruce Arians 5 years later.