The race took place on March 27, on the 1.800-mile (2.897 km) temporary street circuit in St. Petersburg, Florida, and was telecast by ABC in the United States.

Tony Kanaan left Andretti Autosport after the 2010 season and was now piloting the #82 entry for KV Racing Technology – Lotus.

Helio Castroneves made contact with Marco Andretti's car, who ran up the back of Scott Dixon's machine and flipped upside down.

The main point of interest over the final 10 laps was the battle for 3rd place between the veteran Kanaan and second-year driver Simona de Silvestro.

Kanaan was able to hold on and gain a podium place for his new team, KV-Lotus, but it was an impressive run by de Silvestro nonetheless.