The 2010 Cafés do Brasil Indy 300 was an IndyCar motor race held in front of approximately 14,000 people on October 2, 2010, at the Homestead–Miami Speedway in Homestead, Florida.

Dixon's teammate Dario Franchitti won the pole position by posting the fastest two-lap effort in qualifying.

[2] The Cafés do Brasil Indy 300 was the 17th (and final) race scheduled for 2010 by the IRL, and was held on October 2, 2010, in Homestead, Florida, at Homestead–Miami Speedway.

[6] Franchitti, who was familiar with Homestead-Miami Speedway, revealed he would not alter his plan and went to the track to win the race; he acknowledged that eliminating the 13-point deficit would not be easy.

[6] He also noted the high number of entries for the race had the potential to affect the championship battle, "I think the other guys on the track, they've got their own reasons.

"[7] On September 8, IndyCar Chief Executive Officer Randy Bernard announced via e-mail that Homestead–Miami Speedway would not hold a race in 2011.

The Miami Herald reported the track appeared to suffer management-wise because it was owned and operated by International Speedway Corporation which had three other circuits expected for removal from the 2011 season.

[8] Homestead–Miami Speedway's president Matthew Becherer said that he wanted the IndyCar race to remain, but could not do so after the series raised the event's sanctioning fee by 30 percent.

Bernard said while the series was receptive to returning to the track in the future, he blamed the organizers for failing to promote IndyCar.

Dreyer & Reinbold Racing announced eight days beforehand that Ana Beatriz would fill in for regular driver Mike Conway in the team's No.

Conway had been able to return to full fitness following a major accident in the Indianapolis 500 in May but chose not to compete at Homestead–Miami Speedway because he wanted to regain his strength and focus on the 2011 season.

[10] It was Beatriz's fourth race of the season having previously taken part in the rounds at São Paulo, Indianapolis and Chicago.

[11] She was one of five women to compete in the event along with Danica Patrick, Sarah Fisher, Simona de Silvestro and Milka Duno.

[14] Power was fastest in the first practice session with a lap of 25.0824 seconds; Dixon, Briscoe, Franchitti, Castroneves, Dan Wheldon, Marco Andretti, Alex Tagliani, Vítor Meira and Tony Kanaan made up positions two to ten.

Power, who held the pole position for most of qualifying until Franchitti's lap, was third, his teammate Briscoe took fourth and Wheldon fifth.

Behind them, the rest of the grid lined up as: Patrick, E. J. Viso, Mario Moraes, Bertrand Baguette, Beatriz, Andretti, Fisher, Graham Rahal, Tagliani, Ryan Hunter-Reay, Vítor Meira, Alex Lloyd, Raphael Matos, Saavedra, de Silvestro, Hideki Mutoh, and Duno.

[19] After qualifying, Franchitti said, "I don’t know what (crew chief) Chris Simmons did to the Target car between practice and now, but that thing was beautifully balanced.

[25] Castroneves moved from tenth to fifth by the start of lap ten, while his fellow Brazilian Kanaan gained three positions to run in third as Power fell back.

The first caution was necessitated on the 36th lap; Moraes stopped with a mechanical fault in an unsafe section of the track in turn two.

[27] Beatriz exited the pit lane late and slowed on the low part of the apron to allow the field through.

As the field passed her, she accelerated up the bumpy asphalt surface, losing downforce and traction at the rear of her car.

[25] Franchitti slowed slightly on lap 58 because his tires were possibly strained from maintaining a tight line on the right, allowing Briscoe into the lead.

[25] Two laps later, Kanaan and Dixon got ahead of Franchitti as he lost momentum and clear air from his earlier battle with Briscoe.

[28] After the pit stops, Franchitti returned to the lead,[26] closely followed by Kanaan, Dixon, Power, Briscoe, and Castroneves.

[26][28] Power's mechanics instructed him to switch off the engine, and he was taken behind the pit wall for five minutes and six seconds, losing five laps to Franchitti.

[21][28] One of the sidelights informing drivers when the pit lane was open required attention as Meira, Patrick and Kanaan made fuel stops to attempt to manage their usage over the last 50 laps.

[26][27][28] The caution provided some teams with an opportunity to make a final pit stop to allow their drivers to finish the race.

[27] Dixon pulled away, while Castroneves could not match the speed of the two Andretti Autosport cars of Kanaan and the aggressive Patrick, and fell to fourth.

[21] The final finishers were Carpenter, Tagliani, Baugette, Saavedra, Matos, Sato, Viso, Mutoh, Wilson, Fisher, and de Silvestro.

"[35] Power said while he was disappointed not to win the championship,[30] he wanted to come back stronger for the 2011 season after he had not won his first race on an oval track and lost a potential victory at Chicagoland due to a malfunctioning fuel hose.