The postseason began on September 30, 2011, and ended on October 28, 2011, with the Cardinals defeating the Rangers in seven games in the 2011 World Series.

It was the Cardinals' 11th title in franchise history, tying the NHL's Detroit Red Wings for the sixth most championship wins in North American sports.

In a hotly contested five-game series, the Tigers once again defeated the Yankees to return to the ALCS for the second time in six years.

In Game 2, the Tigers jumped out to a 4–0 lead and their bullpen stopped a late rally by the Yankees to even the series headed back to Detroit.

Delmon Young would propel the Tigers to a one-run victory in Game 3 thanks to a solo home run in the bottom of the seventh that broke a 4–4 tie.

However, in Game 5, Fister would redeem himself as he and the Tigers' bullpen fended off a late push by the Yankees to win 3–2 and return to the ALCS.

In the top of the seventh inning of Game 3, Mike Napoli and Josh Hamilton helped the Rangers come from behind to win by a 4–3 score to take the series lead.

Both teams would meet again in the Wild Card round of the 2023 postseason, which the Rangers won in a sweep en route to the World Series.

The Cardinals closed out the series with a 1–0 shutout in Game 5 to advance, thanks to a solid pitching performance from ace Chris Carpenter.

Both teams would meet again in the Wild Card round in 2022, where the Phillies returned the favor by sweeping the Cardinals before falling in the World Series that year.

Game 1 was an offensive slugfest which the Brewers won 9–6, thanks to home runs from Ryan Braun, Prince Fielder and Yuniesky Betancourt.

The Cardinals would clinch the pennant in another blowout win in Game 6, thanks to home runs from David Freese, Rafael Furcal, and Albert Pujols.

†: Postponed from October 26 due to rain[48] Considered to be one of the greatest World Series ever played, the Cardinals defeated the Rangers in seven games to win their eleventh championship in franchise history.

Game 6 was the most memorable contest of the series, in which the Cardinals erased a two-run deficit in the bottom of the ninth inning thanks to a triple by David Freese, then did it again in the tenth.

The Rangers returned to the postseason again next year, but fell to the Baltimore Orioles in the AL Wild Card Game.