The 2011 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2011 NCAA Division I FCS football season.
Led by second-year head coach Karl Morgan, the Delta Devils compiled an overall record of 1–10 and a mark of 1–8 in conference play, tying for fourth place in the SWAC's East Division.
Mississippi Valley State played home games at Rice–Totten Stadium in Itta Bena, Mississippi.
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