They were led by head coach Joey Jones and played their home games at Ladd–Peebles Stadium.

The Jaguars opened the 2011 season at home against the West Alabama Tigers of the Gulf South Conference.

Kendall Houston scored two touchdowns on runs of 2 and 10 yards in the second half for the Jaguars, who broke a 7–7 halftime tie.

Trailing 13–7, West Alabama cut the lead to 13–10 on a 22-yard field goal by Ryne Smith with 10:58 remaining.

Lamar was held to three first downs and 64 yards on offense in the first half as South Alabama scored three times in the second quarter for a 20–0 halftime lead.

[12] South suffered its first loss in program history when the Jaguars fell 35–13 to NC State in Raleigh, North Carolina.

South Alabama kept things competitive into the third quarter of its 35–13 loss to North Carolina State before allowing the Wolfpack's Mike Glennon to throw a career-high four touchdown passes.

Demetre Baker had an 8-yard scoring run and Jordan Means kicked two field goals, including a school-record 46-yarder, for the Jaguars.