The team was coached by Gary Pinkel, who returned for his 11th season, and played their home games at Faurot Field at Memorial Stadium.

The NCAA recognized Missouri's football program for ranking in the top 10% of the country for Academic Progress Rate for the 2011–12 academic year, MU's final year as members of the Big 12.

[1] Key Losses: QB Blaine Gabbert chose to forgo his senior year eligibility and enter the NFL draft in 2011.

[3] Sheldon Richardson, a 6' 4" defensive tackle[4] originally from St. Louis, signed a Letter of Intent to play for the Tigers in 2011.

[7][8] Michael Boddie, Gerrand Johnson, and Wesley Leftwich signed LOI prior to Feb. 3 and enrolled in classes this Spring semester.