CDT; extreme ground scouring, up to .5 metres (1.6 ft) deep in places, occurred in northeastern Neshoba County.

Multiple episodes of tornadic activity ensued with two waves of mesoscale convective systems in the morning hours, followed by a widespread outbreak of supercells from Mississippi to North Carolina during the afternoon into the evening.

[1] Activity on April 27 was precipitated by a 995 mbar (hPa; 29.39 inHg) surface low situated over Kentucky and a deep, negatively tilted (aligned northwest to southeast) trough over Arkansas and Louisiana.

A strong southwesterly surface jet intersected these systems at a 60° angle, an ageostrophic flow that led to storm-relative helicity values in excess of 500 m2s−2—indicative of extreme wind shear and a very high potential for rotating updrafts within supercells.

Ample moisture from the Gulf of Mexico was brought north across the Deep South, leading to daytime high temperatures of 77 to 81 °F (25 to 27 °C) and dewpoints of 66 to 72 °F (19 to 22 °C).

[8] The storm moved through the Pearl River Resort, where it destroyed a historic log cabin,[10] fencing, lighting, and dugouts at two baseball fields.

[13] Along the Kemper-Winston County line, EF5 damage occurred as extremely deep ground scouring took place again and asphalt was ripped from roads.

Nearby, the tornado weakened to EF3 strength as two brick homes were destroyed with barely any interior walls left standing; two people sustained serious injuries.

As it crossed Central McDonald Road, it destroyed a single-wide mobile home and leveled a nearby grove of pine trees.

[9] As the tornado approached the Winston–Noxubee border, it caused substantial roof damage to a church and left impact holes in the back wall.

Along Butler Road, to the southwest of Macon, additional pavement scouring took place, along with the destruction of a shop and a bus being rolled.

[9] Throughout its 30-minute track, the tornado traveled 28.28 miles (45.51 km), killed three people, injured eight others,[9] and caused $1.1 million in damage.

[15] Immediately following the destructive tornadoes, Mississippi Governor Haley Barbour declared a state of emergency for 39 counties.

This allowed residents and some local governments to sign up to receive federal funding to repair damage incurred from the storms.

[16] More than 60 members of the Longino Baptist Church assisted residents of Neshoba County with debris removal and cleaning; also providing refreshments.

[17] Disaster unemployment assistance was made available for people who lost their jobs due to storms and flooding, starting on May 17.