The season started on Friday 28 January with Católica's 2–0 inaugural match win over Deportes Iquique,[1] and concluded on Sunday 12 June in the tournament final won by Universidad de Chile over the same Universidad Católica which didn't repeat its title from previous season.

[2] A total of 18 teams contested the league, including 16 sides from 2010 season, and two promoted from the Primera B that replaced to the relegated Everton (17th) and San Luis de Quillota (18th) after finishing in the aggregate's table bottom.

Deportes Iquique reached the promotion to Primera División after winning the 2010 Primera B de Chile, so that The Dragons recovered their category lost in 2009, closing a brief absence of one season.

[4] The second promoted team was Unión La Calera as Primera B runner-up, so they returned to the top division after a 25-years absence.

Universidad de Chile (regular season second-placed team) played a two-legged tie against Deportes Concepción (2010 Copa Chile Bicentenario runner-up) for the 2011 Copa Sudamericana preliminary stages qualification as Chile 3 berth.