The girls' 100 metres hurdles at the 2011 World Youth Championships in Athletics was held at the Stadium Lille Métropole on 6 and 7 July.

[1] Prior to the competition, the following records were as follows.

Qualification rule: first 4 of each heat (Q) plus the 4 fastest times (q) qualified.

[2] Qualification rule: first 2 of each heat (Q) plus the 2 fastest times (q) qualified.

[3] [4]