[2] The second match will be on 28 July in Tangier, Morocco, versus an all-star starting XI from the Moroccan Football League at the Stade de Tanger.

[13] On 28 July, Barcelona defeated Raja Casablanca 8–0 in Tangier with Lionel Messi supplying a hat-trick while Alexis Sánchez added another two goals while Dani Alves, Sergi Gómez, and Deulofeu scored one each.

[14] On 30 July, Barcelona announced they accepted the rescheduled date of the Supercopa de Catalunya after the Catalan Football Association proposed the match to be played on 26 September 2012.

The two long-time injured Barça players, David Villa (fractured tibia) and Andreu Fontàs (torn ACL), made their returns.

[18] On 18 August, Barcelona and English club Arsenal reached an agreement on the transfer of Cameroon midfielder Alex Song for €19 million.

[19] On 19 August, Barcelona started their 2012–13 La Liga season with 5–1 home win over Real Sociedad with two goals by Lionel Messi and one each by Carles Puyol, Pedro and David Villa.

[22] On 23 August, Barcelona defeated Real Madrid in the first leg of the Supercopa de España, 3–2, with goals by Pedro, Lionel Messi and Xavi.

[23] Messi's 14th Clásico goal allowed him to equal César Rodríguez's record for Barcelona and marked the first time a player scored in four consecutive Spanish Super Cup matches.

[24] On 26 August, Barcelona came back from a 1–0 half-time deficit to defeat CA Osasuna in El Sadar with a 2–1 victory behind two goals from Lionel Messi in the last 15 minutes of the match.

[31] Barcelona midfielder Andrés Iniesta received the 2011–12 UEFA Best Player in Europe Award, beating out teammate Lionel Messi and Real Madrid forward Cristiano Ronaldo for the prize.

After Sevilla took a 2–0 lead, two goals by Cesc Fàbregas and one by substitute David Villa in injury time kept Barça on their perfect start to the league season.

[45] Late in the second half of the game, Carles Puyol suffered yet another injury when he landed awkwardly and dislocated his left elbow.

Goals by Xavi, Cristian Tello and a brace by Lionel Messi helped equalizing the best ever La Liga start after the first 11 games of the season, previously archived by Real Madrid 1968–69 and 1991–92.

President Sandro Rosell stated "(Qatar Airways) an ambitious brand with global aspirations, always committed to achieving the utmost excellence in its field.

One goal by Dani Alves and two by Lionel Messi helped Barça to qualify for the knockout phase of the Champions League with one game left to play.

A brace by Lionel Messi and one goal each by Cesc Fàbregas and Andrés Iniesta, the latter also contributing three assists, as well as a penalty save by Víctor Valdés kept Barça on top of La Liga.

On 1 December, Barcelona defeated Athletic Bilbao 5–1 at home with two goals by Lionel Messi and one each by Gerard Piqué, Adriano, and Cesc Fàbregas.

[75] Early in the game, Cesc Fàbregas was subbed off with a torn biceps femoris in his left thigh and will be sidelined for three-to-four weeks.

[80] On 19 December, Barcelona's Medical Services announced that manager Tito Vilanova was to undergo surgery on the following day after a routine check-up revealed that he suffered a parotid ailment relapse, which he was operated on a year previous.

[84] On 23 December, Barcelona announced that backup goalkeeper José Manuel Pinto came to an agreement with the club to extend his contract for another year until 30 June 2014.

[87] With 41.60% of the votes, Messi became the first player to win the award on four occasions, surpassing Johan Cruyff, Michel Platini and Marco van Basten, all with three.

[89] On 10 January, Barcelona beat Córdoba in the return leg of the Copa del Rey at home by 5–0, with one goal scored by Thiago and two each by David Villa and Alexis Sánchez.

[90] Early in the second half of the game, Sergi Roberto was subbed off with a tear in his left hamstring and will be out of action for four weeks.

[101] On the same day, Barça announced that defender Marc Muniesa will join the B team for the rest of the season after having recovered from a torn ACL.

[104] Barcelona faced Milan in the first leg of the Champions League round of 16 at the San Siro and lost 2–0, with goals coming from Kevin-Prince Boateng and Sulley Muntari.

[105] On 21 February, Barcelona announced that defender Eric Abidal is fit to play for the first time since receiving a liver transplant in April 2012.

Four days later, Víctor Valdés was handed a four-match league ban after receiving a double yellow card for verbally abusing a referee following his team's defeat in the Clásico in the weekend fixture.

[110] On 12 March, Barcelona defeated Milan 4–0, 4–2 on aggregate, and entered the quarter-finals of the Champions League with goals from David Villa, Jordi Alba and a brace from Lionel Messi.

[113] On 2 April, Barça drew 2–2 against Paris Saint-Germain in France in the first leg of the Champions League quarter-final, the goals coming from Messi and Xavi via a penalty.

On 5 May, Barcelona defeated Real Betis 4–2 at home with two goals by Lionel Messi and one each by David Villa and Alexis Sánchez with one more win to secure the La Liga title.