The 2012 Barcelona Ladies Open was a women's tennis tournament played on outdoor clay courts.

It was the 6th edition of the Barcelona Ladies Open, and an International-level tournament on the 2012 WTA Tour.

It took place at the Centre Municipal Tennis Vall d'Hebron in Barcelona, Catalonia, Spain between April 9 and 15, 2012.

Sara Errani won the singles title.

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: