The Seminoles were led by third-year head coach Jimbo Fisher, and played their home games at Bobby Bowden Field at Doak Campbell Stadium in Tallahassee, Florida.

[2] With the late cancellation, Florida State was forced to add another Football Championship Subdivision team to its schedule.

[3] On August 1, 2012, Florida State kicked senior cornerback and punt return specialist Greg Reid off the team.

[5] The annual 'Garnet and Gold Game' was held on April 14 at Bobby Bowden Field at Doak Campbell Stadium and the garnet team was victorious, winning by a score of 35–20.

Defensive coordinator Mark Stoops left his position at Florida State to take the job as head coach at Kentucky.

Florida State added another thirteen points in the second quarter as the result of a 19-yard touchdown run from James Wilder, Jr. and another 1-yard touchdown run from James Wilder, Jr. with a subsequent failed point-after-attempt from kicker Dustin Hopkins, ending his streak of 145 consecutive extra point attempts.

Florida State scored another seven points in the third quarter as the result of a 19-yard touchdown pass from Jacob Coker to Kelvin Benjamin.

Clemson defeated Florida State the previous season 35–30 at Death Valley en route to the Atlantic Division title and an ACC Championship.

Florida State had many miscues that kept them from points, including two fumbles, two missed field goals, and a questionable 4th down call that kept them from leading.

In the second half, Clemson extended their lead to fourteen when Boyd connected to Sammy Watkins on a bubble screen who then threw the ball to Andre Ellington for a 52-yard touchdown.

Florida State responded with a 1-yard touchdown pass from EJ Manuel to tight end Kevin Haplea and later extended their lead again with a 23-yard field goal from Hopkins.

Florida State went on to control the second half of the game as well, holding Boston College scoreless in both the third and fourth quarters.

In the third quarter, Florida State scored twice with a 3-yard touchdown run from Lonnie Pryor and a 26-yard field goal from Dustin Hopkins.

They then scored on a 75-yard punt returned for a touchdown by Tyler Hunter and then added to that lead with a 26-yard field goal from Dustin Hopkins.

On special teams, Tyler Hunter returned a punt for a touchdown and Dustin Hopkins successfully attempted two field goals, including the longest of his career.

Late in the quarter, Virginia Tech took the lead for the first time with a 4-yard touchdown pass from Logan Thomas to Corey Fuller.

Tyler Hunter made a key interception in the red zone to prevent Tech from scoring and secure a victory for the Seminoles.

Maryland scored their first points of the game early in the third quarter with a 33-yard touchdown pass from Shawn Petty to Kevin Dorsey to cut the Seminole lead to twenty.

Maryland's only other score came in the final seconds with another 42-yard touchdown pass from Shawn Petty to Kevin Dorsey following a State turnover.

On special teams, Dustin Hopkins successfully attempted two field goals, making him the all-time NCAA scoring leader with 448 points.

[83] This was the second consecutive victory for the Seminoles after a win the previous season in Tallahassee that snapped a six-game losing streak to the Gators.

Their lead was extended courtesy of a 14-yard pass from Jeff Driskel to Quinton Dunbar and a 32-yard touchdown run from Matt Jones.

Georgia Tech was named champions of the Coastal Division due to Miami self imposing a post-season ban and North Carolina being under NCAA sanctions making both teams ineligible.

Georgia Tech put their first points on the board with a 27-yard field goal from Chris Turner to cut the Seminoles lead to eleven.

Florida State scored again courtesy of another 1-yard touchdown run from James Wilder, Jr. Before halftime, Georgia Tech kicked a 47-yard field goal to give the Yellow Jackets three more points.

Georgia Tech got the ball back and were driving down the field in the final minutes until Karlos Williams intercepted in Florida State territory, which enabled the Seminoles to take a knee and claim a win over the Yellow Jackets.

The Seminoles scored in the first quarter with a 60-yard touchdown run from eventual MVP Lonnie Pryor to give them an early seven to zero lead.

Late in the second quarter, Florida State built up their lead with a 6-yard touchdown pass from EJ Manuel to Rashad Greene.

[93] In addition to pre-season watchlists, four Florida State players were added to the lists after the season began:[94] Björn Werner, Chris Thompson, Cornellius Carradine, EJ Manuel, Menelik Watson, Lamarcus Joyner, Dustin Hopkins, Telvin Smith, Christian Jones, Ronald Darby, and Rashad Greene have all been honored with ACC Player of the Week recognitions for their respective games.

[116] Second Team OffenseEJ Manuel (QB)Chris Thompson (RB)Tre' Jackson (G)Bryan Stork (C) Honorable Mentions (offense)Rashad Greene (WR)Nick O'Leary (TE)Cameron Erving (T)Menelik Watson (T)Josue Matías (G) First Team DefenseCornellius Carradine (DE)Björn Werner (DE)Xavier Rhodes (CB)Lamarcus Joyner (S) Second Team DefenseTimmy Jernigan (DT)Everett Dawkins (DT)Christian Jones (LB) Honorable Mentions (defense)Anthony McCloud, Sr. (DT) First Team Special teamsDustin Hopkins (K) Defensive player of the yearBjoern Werner (DE) Defensive rookie of the yearRonald Darby (CB) Coach of the Year Runner-UpJimbo Fisher Four Florida State players have been honored with All-American selections.