The 2021 Pittsburgh Panthers football team represented the University of Pittsburgh in the 2021 NCAA Division I FBS football season.

The Panthers were led by seventh-year head coach Pat Narduzzi and played their home games at Heinz Field.

They competed in the Atlantic Coast Conference (ACC), marking Pitt's ninth season as a member of the ACC.

The Panthers won the ACC Championship with a record of 11–2 and a 45–21 victory over Wake Forest in the 2021 ACC Championship Game, becoming the first school other than Clemson or Florida State to win the conference championship since Virginia Tech in 2010.

Source:[1] Roster Last update: October 25, 2024 at Heinz Field, Pittsburgh, PA at Neyland Stadium, Knoxville, TN at Heinz Field, Pittsburgh, PA at Heinz Field, Pittsburgh, PA at Bobby Dodd Stadium, Atlanta, GA at Lane Stadium, Blacksburg, VA at Heinz Field, Pittsburgh, PA at Heinz Field, Pittsburgh, PA at Wallace Wade Stadium, Durham, NC at Heinz Field, Pittsburgh, PA at Heinz Field, Pittsburgh, PA at Carrier Dome, Syracuse, NY at Bank of America Stadium, Charlotte, NC at Mercedes Benz Stadium, Atlanta, GA