No club was promoted to the Thai Division 1 League.
Last years league champions Kasetsart University and runners up North Bangkok College failed to qualify from the 2011 Regional League Division 2 championship pool.
Maptaphut Rayong, Royal Thai Fleet, Thanyaburi United have all been moved into the Central-East Region 2012 Paknampho NSRU moved into the Division 2 League Northern Region 2012 Raj-Vithi have withdrawn from the 2012 campaign.
Central Lions (previously known as (North-Central) is returning to the league.
Krung Thonburi, Rangsit (Wongprachanukul Stadium) Pathum Thani Nong Chok, Bangkok Thupatemi Stadium BEC Tero Sasana Nong Chok Stadium 25,000 5,000 Lak Si, Bangkok