No club was promoted to the Thai Division 1 League.
Last year's league champions, Phitsanulok, and runners up, Lamphun Warrior, failed to qualify from the 2011 Regional League Division 2 championship pool.
Chiangmai were relegated from the 2011 Thai Division 1 League.
Paknampho NSRU relocated to the Regional League Northern Division from the Regional League Bangkok Area Division.
[5] Tak Provincial Administrative Organization Stadium (2) 3,100 [17] Chiangrai PAO.