The 2012 Campeonato Nacional Clausura Petrobras was the 91st season of the Chilean Primera División.

The champion was Huachipato, winning their 2nd league title, 38 years after their first championship.

It was, as of 2023, the last Chilean top-flight tournament to be decided by playoff stage.

For all ties, the lower-seeded team play the first leg at home.

Universidad de Concepción is relegated to Primera B. Cobresal won 4–3 on aggregate and therefore both clubs remain in their respective leagues.