Bunyodkor were the defending champions from the 2011 campaign.
The draw for the 2012 Uzbek League season took place on January 6, 2012.
[1] FK Guliston was officially out of the season, and was replaced by Qizilqum Zarafshon, the reason for absence were financial problems of the club.
[2] - The 4+1 format of foreign players has been reduced to 3+1.
See also Coach and Player of Month Last updated: 21 November 2012 Source: Soccerway