The Cup draw was held on January 25, 2012 in Tashkent.
[1] The competition started on 23 March 2012 and ended on 30 November 2012 with the final at the Pakhtakor Markaziy Stadium in Tashkent.
The cup winner were guaranteed a place in the 2013 AFC Champions League.
Note: The one leg matches were played on 29–31 March.
The sixteen winners from the Round of 32 were drawn into eight two-legged ties.