Sources: [1][2] Baylor opened its final season in Floyd Casey Stadium at home against the Wofford Terriers, a late addition to the 2013 schedule after SMU canceled their 2013 matchup against the Bears.

Baylor's defense shut down the Terrier's triple-option attack, limiting Wofford to 173 rushing yards on the night, forcing three turnovers, allowing no touchdowns, and giving up only a field goal in the 3rd quarter.

Buffalo drew first blood, capitalizing on a 54-yard completion from Joe Licata to Alex Neutz on the first play from scrimmage and subsequently scoring on a 1-yard Branden Oliver rush.

Baylor received the ball to open the game and scored on a 12-play, 59 yard drive that was kept alive by a crucial penalty on KSU defender Randall Evans, who hit QB Bryce Petty out of bounds on a 3rd and 11 play.

After Kansas State settled for a field goal on their next possession, Petty hit Antwan Goodley for a 72-yard touchdown and the teams entered the half with Baylor leading 21–10.

The Wildcats received the ball to open the half and drove to set up a field goal to cut Baylor's lead to 8; during this drive Kansas State used two of their three second-half timeouts.

With Oklahoma being upset in the Red River Shootout by the Texas Longhorns on the same weekend, Baylor also became the highest ranking Big 12 team in both polls for the first time in league history.

[13][14][15][16] Back in Waco after their first road game of the season, the Baylor Bears hosted Iowa State as part of the nation's oldest Homecoming celebration.

The Bears would immediately answer, as Corey Coleman returned the ensuing kickoff 97 yards for a touchdown to give Baylor its 4th game of the season with 70 or more points scored.

[17][18] During the weekend, half of the teams ranked above #12 Baylor in the AP and Coaches' polls suffered losses, including #11 South Carolina (to Tennessee), #9 UCLA (to #13 Stanford), #8 Louisville (to UCF), #7 Texas A&M (to #24 Auburn), #6 LSU (to Ole Miss), and #3 Clemson (to #5 Florida State).

The defense shut out the Jayhawk offense in the first half; Kansas would eventually get on the scoreboard with a 22-yard rush off an option pitch in the 3rd quarter and would add a passing touchdown in the 4th.

However, after Baylor's offense took possession under the shadow of their own goalposts, the Sooner defense put up Oklahoma's first points of the game two plays later, sacking QB Bryce Petty in the endzone for a safety.

On the Sooners' next play from scrimmage, linebacker Eddie Lackey picked off Blake Bell to set up a touchdown pass from Petty to Antwan Goodley with 13 seconds remaining in the 2nd quarter.

Baylor's victory came despite multiple injuries, most significantly a dislocated wrist suffered by WR Tevin Reese, which forced him to miss the rest of the regular season.

[27][28][29] A week after the program's second-ever win over Oklahoma, undefeated Baylor faced Texas Tech in Cowboys Stadium in the 5th neutral-site game of their rivalry.

Playing inspired football, the Red Raiders received the ball first and quickly attained a 14-point lead behind a pair of touchdown passes to TE Jace Amaro (the first from RB Kenny Williams, and the second from QB Baker Mayfield) on their opening offensive possessions.

The next Texas Tech possession was cut short by an athletic interception at the line of scrimmage by blitzing cornerback KJ Morton, setting up a 1-play Baylor scoring drive when Petty hit WR Antwan Goodley for a 31-yard touchdown.

After Texas Tech turned the ball over on downs on its ensuing drive, the Bears went ahead 49–27 on Devin Chafin's second TD rush of the night, this time a 47-yard scoring run.

Baylor also advanced in the BCS rankings to #4, displacing Stanford after the Cardinal suffered their second loss of the season at unranked Southern Cal.

Oklahoma State opened the second half with a 76-yard touchdown drive to increase their lead to 21–3; the Cowboys would force a Baylor turnover on downs and immediately score again to hand the Bears a 25-point deficit with just over 10 minutes remaining in the 3rd quarter.

The high-flying Baylor offense continued to struggle on its ensuing drives, fumbling once more and turning the ball over on downs twice before Oklahoma State would again strike to make the score 35–3 at the end of the 3rd quarter.

[32][33] Looking to rebound from their first loss of the season, the 9th ranked Bears traveled to Fort Worth to face one of their most-played rivals, the TCU Horned Frogs.

On their final possession with under two minutes remaining in the game, the Horned Frogs put together a 50-yard drive that brought them to first down at the Baylor 23 yard line, in range for a game-tying field goal and with time for multiple strikes to the end zone to score a game-winning touchdown.

However, with 11 seconds remaining in the game, Pachall threw a pass to the end zone that was tipped by LB Sam Holl and intercepted by S Terrell Burt to seal the Baylor victory.

[34][35] In a clash of top 25 teams, the Baylor Bears and the Texas Longhorns faced off in the final game in the 64-season history of Floyd Casey Stadium.

As both teams entered the game having only lost in conference play to Oklahoma State, the winner of the matchup was assured at least a share of the Big 12 championship.

Baylor received the ball to open the second half and promptly put together a deliberate 14-play, 77-yard drive capped by an 11-yard, one-handed touchdown reception by WR Antwan Goodley from QB Bryce Petty.

The Baylor defense would again force a Texas punt, and the Bears offense would score for a third time on their third possession of the second half when Aaron Jones converted a 42-yard field goal.

The score would remain 20–3 until early in the 4th quarter, when McCoy, scrambling in the backfield on a broken play, found RB Malcolm Brown in the back of the end zone for a 2-yard touchdown pass.

[36][37] The Bears were upset by the UCF Knights, who out gained them in total yards and won time of possession, despite Baylor winning the turnover battle three to one.