Greg Biffle finished second, while Juan Pablo Montoya, Jimmie Johnson, and Kurt Busch rounded out the top five.
Kasey Kahne followed in the second position, while Austin Dillon, Clint Bowyer, and Matt Kenseth rounded out the top five.
In the first Duel, consisting of cars that had qualified in an odd-numbered position, 2011 Daytona 500 winner Trevor Bayne dominated the race until Denny Hamlin lost control of his car on lap 53, crashing into Montoya, Edwards, and Bayne, ending their races.
Kevin Harvick took over the race lead and captured the first Duel, with Scott Speed taking the transfer spot.
With no cautions, Kyle Busch took the lead after crew chief Dave Rogers made the call to take only fuel.