Juan Pablo Montoya, Brian Vickers, and Joey Logano rounded out the top five.
After a lap 259 debris caution, Kenseth was caught speeding on pit road and relegated to the back, while Paul Menard stayed out to take the lead.
Juan Pablo Montoya finished third, and Brian Vickers and Joey Logano rounded out the top five.
Drivers involved in seven, mostly minor, crashes included Ryan Truex, Josh Wise, Clint Bowyer, Tony Raines, Jimmie Johnson, David Reutimann, Aric Almirola, and Jeff Burton.
The eleventh caution on lap 448, as Hamlin blew a tire and ran into Ryan Newman, causing a large crash also involving Brad Keselowski, Martin Truex Jr., Terry Labonte, David Stremme, Casey Mears, David Ragan and Kevin Harvick.