The knock-out stage of the 2013 CAF Confederation Cup was played from 6 October to 30 November 2013.
Knock-out ties were played on a home-and-away two-legged basis.
If the sides were level on aggregate after the second leg, the away goals rule was applied, and if still level, the tie proceeded directly to a penalty shoot-out (no extra time was played).
TP Mazembe won 3–1 on aggregate and advanced to the final.
[3] The draw was held on 14 May 2013, 14:00 UTC+2, at the CAF Headquarters in Cairo, Egypt.