The 2013 U.S. Men's Clay Court Championships was a men's tennis tournament played on outdoor clay courts.

It was the 45th edition of the U.S. Men's Clay Court Championships, and an ATP World Tour 250 event.

It took place at River Oaks Country Club in Houston, Texas, United States, from April 8 through April 14, 2013.

Fifth-seeded John Isner won the singles title.

The following players received wildcards into the main draw: The following players received entry via the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: