The 2013 USA Pro Cycling Challenge was one of six UCI-ranked stage races in the United States in 2013, and one of two (along with the 2013 Tour of California) that attracted multiple UCI ProTeams to compete.

American Tejay van Garderen of BMC Racing Team won the overall title after finishing lower on the podium the previous two years.

[4][5] Other contenders included Australian Rory Sutherland of Saxo–Tinkoff, Jamis–Hagens Berman's Janier Acevedo of Colombia, Irishman Philip Deignan of UnitedHealthcare, RadioShack–Leopard's George Bennett of New Zealand, and Americans Tom Danielson of Garmin–Sharp and Tejay van Garderen of BMC Racing Team.

[4][5] Garmin–Sharp's Lachlan Morton of Australia, and BMC Racing Team's Mathias Frank of Switzerland were both considered potential dark horses.

For the general classification, calculated by adding the finishing times of the stages per cyclist, the leader receives a yellow jersey.

[39] Points are gathered at sprint line performances as well as finishing the stage in the top-fifteen places.

[40] It is generally awarded to a rider who attacks constantly or spends a lot of time in the breakaways.