Originally announced on August 4, 2010 by Colorado Governor Bill Ritter and Lance Armstrong as the Quiznos Pro Challenge,[1] the event carried on the state's cycling legacy, which was most notably highlighted by the Coors Classic that ran from 1980 to 1988.

The USA Pro Cycling Challenge was one of only three current 2.HC rated races in the United States (along with the Tour of California, and the Tour of Utah), and was considered one of the most important pro cycling races in the U.S. After the 2015 edition, Schaden was unable to find a title sponsor for the 2016 edition, and subsequently left as an investor.

The race received 25 hours of national television airtime on Versus and the NBC Sports Network and was seen by over one million people worldwide.

On-air commentary was provided by Tour de France announcers Paul Sherwen, Phil Liggett and Bob Roll.

American Tejay van Garderen of CCC Pro Team won the overall title after finishing lower on the podium the previous two years.