[6] Rodrigo and André Gomes' economic rights had been sold to an investment firm on 31 January;[7][8] in July, they moved to Valencia on loan.

A severely remodeled squad, only presented seven starters of the Taça de Portugal final played just two months earlier: Luisão, Maxi Pereira, Ruben Amorim, Eduardo Salvio, Enzo Pérez, Nicolás Gaitán and Lima.

Benfica dominated throughout the match but was unable to score on multiple occasions, finally beating Rio Ave on penalties, after Artur defended three of them.

On 17 August, in the league's first day, Benfica beat Paços de Ferreira (2–0) with goals from Maxi Pereira and Salvio, with Artur saving a penalty in the 10th minute.

[16] Additionally, Benfica won the first matchday ten years later; the first with Jorge Jesus and the second during the ten-year term of Luís Filipe Vieira.

[18] During the match, played in an artificial turf, Ruben Amorim got severely injured,[19] with news in next day reporting an anterior cruciate ligament injury.

Nicolás Gaitán scored the first goal, while Artur made a mistake which allowed Islam Slimani to tie the match.

It was also the first time in seven seasons that Sporting made any points in a league match against Benfica, while playing as a visitor at the Lisbon derby.

On 12 September, after the early break for the Euro 2016 qualifying, Benfica returned with a 0–5 win at Vitória de Setúbal, with a hat-trick from Talisca, in his first goals in the Primeira Liga.

[23][24] On 21 September, Benfica struggled to defeat Moreirense, suffering an early goal from João Pedro in the debut of Júlio César.

[27] Nonetheless, four days later Benfica won 4–0 against Arouca, in the debut of Lisandro López, Jonas and Pizzi, maintaining the lead in Portuguese league.

On 4 November, Benfica beat Monaco with a goal from Talisca and secured the first victory in group stage of Champions League.

On 22 November, Benfica advanced to the fifth round of the Taça de Portugal by beating Moreirense (4–1), with Jonas and Salvio scoring two goals each.

On 6 December, Benfica continued leading the Portuguese league by defeating Belenenses (3–0) with goals from Lima, Pérez, and Salvio.

On 10 January, Benfica defeated Vitória de Guimarães (3–0) with goals from Jonas, Ola John and Nicolás Gaitán.

[33][34] On 21 January, Benfica won at Moreirense (0–2) and secured the first place in the Taça da Liga's Group A with nine points, advancing to the semi-finals, without conceding a goal.

On 26 January, Benfica lost at Paços de Ferreira (1–0) from a penalty kick in the 90th minute, ending the series of consecutive wins (9) and clean sheets (7) in the league.

On 8 February, Benfica drew at Sporting CP (1–1) with a last-minute goal from Jardel in the 94th minute,[35] and continued leading the Primeira Liga with 4 more points than the second classified.

On 28 February – on the club's 111th anniversary – Benfica thrashed Estoril (6–0) with goals from Luisão, Salvio, Pizzi, Jonas (2) and Lima; and set the league's biggest home win.

On 17 May, Benfica drew at Guimarães (0–0) and became Portuguese champions for a second consecutive time, with one game to spare, three points ahead of Porto, which had drawn at Belenenses.