The knock-out stage of the 2014 CAF Confederation Cup was played from 20 September to 6 December 2014.
Knock-out ties were played on a home-and-away two-legged basis.
If the sides were level on aggregate after the second leg, the away goals rule was applied, and if still level, the tie proceeded directly to a penalty shoot-out (no extra time was played).
[1][4] Séwé Sport won 1–0 on aggregate and advanced to the final.
In the final, the order of legs was decided by a draw, held after the group stage draw (29 April 2014, 11:00 UTC+2, at the CAF Headquarters in Cairo, Egypt).