[4] Researchers generally believe that a two-year-old boy,[5] later identified as Emile Ouamouno, who died in December 2013 in the village of Meliandou, Guéckédou Prefecture, Guinea, was the index case of the current Ebola virus disease epidemic.

[12] The initial cases were thought to be malaria, an extremely common disease in Liberia, and thus leading to doctors being infected with the Ebola virus.

[15] The nurse was treated at Redemption Hospital, a free state-run health care facility in New Kru Town, west of Monrovia.

[27] On 18 August, a mob of residents from West Point, an impoverished area of Monrovia, descended upon a local Ebola clinic to protest its presence.

The protesters turned violent, threatening the caretakers, removing the infected patients, and looting the clinic of its supplies, including blood-stained bed sheets and mattresses.

[43] On 25 September, Liberia's chief medical official went on a self-enforced quarantine after her assistant died from the disease, fearing she might have been accidentally exposed to the virus.

[45] A few days later, on 28 September Ivory Coast resumed flights to Liberia which had been suspended since 11 August 2014, after WHO's critique for tending to economically strangle the affected nations.

[26] On 30 September, a cameraman was tested positive for Ebola in a Texas hospital after contracting the disease before traveling back to the United States from Liberia.

[48] In early October, Ellen Johnson Sirleaf, the President of Liberia, continued requesting more aid to fight the disease.

[60] On 19 October, the President of Liberia apologized to the Mayor of Dallas, for the Liberian national that brought the disease to the United States.

[64] The 5 November WHO situation report noted that, "There appears to be some evidence of a decline at the national level in Liberia, although new case numbers remain high in parts of the country.

"[65] A report by CDC released on 14 November, based on data collected from Lofa county, indicates that there has been a genuine reduction in new infections.

[66] Roselyn Nugba-Ballah led the Safe & Dignified Burial Practices Team for the Liberian Red Cross and was awarded the Florence Nightingale Medal for her work during the crisis in 2017.

[69][70] On 4 December, it was reported that President Sirleaf banned all rallies and gatherings in Monrovia before the senatorial election, fearing that the risk of the Ebola virus spreading may be increased.

[77] On 5 March Tolbert Nyeswah, the assistant health minister of Liberia, reported that the country have released their last confirmed case of Ebola from a Chinese-staffed treatment centre.

On 20 March Moses Massaquoi, leader of the Clinton Health Access Initiative in Liberia, reported a new confirmed case in the country.

[84][87] By 2 July a third new case was confirmed leading to the possibility that they might have been infected with the Ebola virus lurking in animal meat according to researchers.

[90] After two months of going Ebola-free, on 20 November, a new case was confirmed when a 15-year-old boy was diagnosed with Ebola[91][92] and two family members subsequently tested positive as well.

[93][94] Health officials were concerned because the child had not recently travelled or been exposed to someone with Ebola and the WHO stated, "we believe that this is probably again, somehow, someone who has come in contact with a virus that had been persisting in an individual, who had suffered the disease months ago."

[101] After having completed the 42 day time period, Liberia was declared free from the virus on 14 January 2016, effectively ending the outbreak started in neighbouring Guinea two years earlier.

[115] A journalist inside West Point told a local radio station that Liberian soldiers and police were seen "daily soliciting monies from those being quarantined in the area to escape".

"[116] An American non-governmental organization journalist reported that Liberian police threatened arrest and demanded bribes in order for him to leave the MSF compound.

"Very, very few of those dying in the community are being brought forward," said Cokie van der Velde, who organized the collections of bodies with Médecins Sans Frontières.

The assistant Liberian health minister announced at the time that an assessment of Ebola treatment units discovered that out of the 742 beds only 351 were occupied by patients.

[120] The non-reporting is believed to be due to a policy decision in August to cremate all bodies of suspected Ebola cases in Monrovia.

[120] On 6 August 2014, President Sirleaf, in an emergency announcement, informed absent government ministers and civil service leaders to return to their duties in Liberia.

[134] Kent Brantly, a physician and medical director in Liberia for the aid group Samaritan's Purse, and co-worker Nancy Writebol were infected while working in Monrovia.

[139] A French volunteer health worker working for MSF in Liberia contracted Ebola there and was flown to France on 18 September 2014.

[142] On 24 May 2016, Liberian Child's right and Environmental Activist, Chair-Person of the National Children and Youth Advisory Board Wantoe Teah Wantoe, acknowledged The United Nations body, Government body, and civil society actors at the World Humanitarian Summit through his Preliminary address Archived 2 January 2019 at the Wayback Machine on the need to contribute to Liberia's resilience and recovery after the casualties of the Ebola virus disease.

He spoke of the vulnerabilities of Liberian children whose status had been changed to orphans and semi-orphans due to the deaths caused by the Ebola virus.