In contrast to a poor local election result, Fine Gael retained 4 seats, remaining the largest Irish party at a European level.

In Dublin, Lynn Boylan of Sinn Féin topped the poll and a tight four-way battle for the remaining two seats ensued between Brian Hayes of Fine Gael, ex-Labour MEP turned independent Nessa Childers, Fianna Fáil's Mary Fitzpatrick and the Green Party's Eamon Ryan.

In South, both Brian Crowley of Fianna Fáil and Seán Kelly of Fine Gael were re-elected while first time candidate Liadh Ní Riada of Sinn Féin won a seat.

In the new Midlands–North-West constituency, independent TD Luke 'Ming' Flanagan topped the poll while Mairead McGuinness of Fine Gael and Sinn Féin's Matt Carthy took the next two seats.

Fianna Fáil's two-candidate strategy in the constituency backfired, with sitting MEP Pat "the Cope" Gallagher narrowly losing to independent Marian Harkin.