Rosenqvist led the majority of the main race to become the first Swedish driver to win the Grand Prix itself since Rickard Rydell won the 1992 event.

All-Japan Formula Three title holder Nobuharu Matsushita did not enter the race and so the highest-placed Japanese series driver in Macau was the runner-up Kenta Yamashita.

[5] The entry list included one woman driver, Tatiana Calderón, the first female entrant in Macau since Cathy Muller raced in the 1983 edition.

[6] Euroformula Open driver Yu Kanamaru was called up by Carlin as a late replacement for Jake Dennis who opted to withdraw from the race.

[14] For the first time in the event's history, the Macau Grand Prix Committee imposed an average noise limit level to a maximum of 115 decibels to support environmental initiatives and reduce residential disturbance.

His closest challenger was Antonio Giovinazzi ahead of teammate Tom Blomqvist, Buller, Jordan King, Felix Rosenqvist, Max Verstappen, Nicholas Latifi, Coletti and Sean Gelael.

[16] Wells spun into the wall at Fisherman's bend and Mitsunori Takaboshi stopped the session by hitting the Moorish Hill turn barrier.

[15] Spike Goddard hit the Moorish Hill corner wall in the closing minutes and prevented improvements on drivers' quickest lap times.

[17] Following him were Gelael, Antonio Fuoco, Santino Ferrucci, Félix Serrallés, Pommer, Álex Palou, Kanamaru, Merhi and Gustavo Menezes, Yamashita, Goddard, Wells, Cao, Calderón, MacLeod, Wing Chung Chang and Takaboshi.

[18] The session passed relatively smoothly with only Cao crashing into the barrier at Fisherman's Bend and Calderón hitting the wall at Police corner.

[22] Fuoco crashed heavily at Fisherman's Bend after ten minutes; a red flag was not necessitated since marshals were able to remove his car from the track.

[24] The session ended early when Rosenqvist removed his car's front wing after he hit the wall at Maternity Bend.

[25] Auer was qualifying's early pace setter before Ocon, looking to record as fast a time as possible in order to minimise his potential grid loss, moved ahead soon after.

[26] Behind them the rest of the field lined up as Pommer, Coletti (competing with a broken finger), Gelael, Palou, Buller (ill with food poisoning), Serrallés, Fuoco, Ferrucci, Kanamaru, Cao, Calderón, Goddard, Yamashita, Menezes, Wells, Takaboshi, Chang and MacLeod.

[29] At the start, Auer accelerated faster than Rosenqvist off the line and slipstreamed up behind his teammate and moved into the lead before entering Mandarin Oriental corner.

As Giovinazzi slid violently across the circuit, he hit Gelael,[30] who made an unscheduled pit stop and Buller did the same after sustaining car damage.

[31] Auer now held a two-second advantage over the rest of the field,[32] with the hope that no accidents would occur that would necessitate the safety car's deployment.

He broke his front-left suspension in an impact with a wall after a rear brake locking meant he missed the apex by approximately 3 cm (1.2 in).

[31] The safety car was required on the same lap when MacLeod crashed and blocked half the track at Paiol corner since no recovery cranes were in the area.

Blomqvist resisted an pass from Ocon to maintain third, while Latifi retook seventh from King and Coletti lost ninth to Serrallés.

The Japanese duo of Kanamaru and Yamashita, Menezes, Calderón, Cao, Goddard, Pommer, Takaboshi, Chang and Wells rounded out the classified finishers.

[33] When it began from its standing start at 15:30 local time on 16 November,[4] Auer moved into the lead into Lisboa corner for the second day running from the slow-starting Rosenqvist whom Blomqvist and Ocon overtook to demote him to fourth.

Additionally, one of Pommer's front wheels dangled off its suspension rod and Fuoco appeared to have sustained bodywork damage.

Fuoco chose to drive into the pit lane since his team repaired the front of his car until the last minute before the restart.

I’ve never won the European championship but to win the big ones (Pau, Zandvoort and Macau) is very special.” Soon after, King was another retiree as he parked his car two laps after the restart with a punctured tyre,[34] while Serrallés drove slowly to the pit lane to replace a dislodged front wing.

[40] Despite car floor damage and an oil leak,[39] Verstappen's pace allowed him to overtake teammate Menezes, Yamashita into Lisboa corner and Ferrucci settled for seventh.

[38] Merhi lacked straightline speed and pushed hard at the R Bend in an effort to cling onto Cassidy's slipstream but defended from Latifi after an error.

[20] On his fifth appearance at Macau,[41] it was Rosenqvist's victory, achieving the first win for a Swedish driver in the Grand Prix since Rickard Rydell won the 1992 race.