[3][4] In 2013, Fuoco graduated to single-seaters, racing in the newly launched Formula Renault 2.0 Alps series for Prema Junior.

[9] Despite scoring two podiums, Fuoco experienced an inconsistent season, including crashes at the Red Bull Ring, the Hungaroring, Spa and Monza.

In February 2016, following Carlin's departure from the series, it was announced Fuoco would be racing for Trident, where he collected his maiden victories and finished third in the championship.

In November 2016, it was announced that Fuoco would graduate to the series, reunite with Prema and partner fellow Ferrari junior and GP3 champion Charles Leclerc for the 2017 season.

[19] The opening round at the 1000 Miles of Sebring began with a positive surprise, as Fuoco took the brand's first pole in the top class of the Championship.

[20] In 2024, Fuoco, along with Nielsen and Molina of the number 50 Ferrari AF Corse team, won the 24 Hours of Le Mans in the Hypercar category.