Incumbent Republican Governor Matt Mead ran for re-election to a second term in office.

He was challenged in the primary by physician and rancher Taylor Haynes and Superintendent of Public Instruction Cindy Hill, defeating them by 54% to 32% to 13%.

In the general election, he defeated former Chairman of the Wyoming Democratic Party Pete Gosar, Independent Don Wills and Libertarian Dee Cozzens by 58% to 27% to 6% to 2%.

Incumbent Republican senator Mike Enzi ran for re-election to a fourth term in office.

He defeated Democrat Charlie Hardy, Independent Curt Gottshall and Libertarian Joseph Porambo in the general election.