The 2015–16 Grand Canyon Antelopes men's basketball team represented Grand Canyon University during the 2015–16 NCAA Division I men's basketball season.

This was head coach Dan Majerle's third season at Grand Canyon.

However the Antelopes were eligible for the CIT, CBI or the new Vegas 16 tournaments if invited.

In the first round, they defeated South Carolina State to be champions of the Coach John McLendon Classic, the first classic game to be held as part of a postseason tournament.

In the second round they defeated Jackson State to advance to the quarterfinals where they lost to Coastal Carolina.