The 2015–16 season of the Guadeloupe Division d'Honneur is the 65th season of top-tier football in Guadeloupe.
CS Moulien were the defending champions, having won their 11th top tier title last season.
USR won their first title this season.
At the end of last season, AS Gosier and Racing Club finished in 13th and 14th place in the league and were relegated to the Promotion d'Honneur Régionale.
Taking their places were the winners and runners up from the Promotion d'Honneur Régionale, Amical Club and Gourbeyrienne.