The 2015–16 Saint Louis Billikens women's basketball team represented the Saint Louis University during the 2015–16 college basketball season.

The Billikens, led by fourth year head coach Lisa Stone, were members of the Atlantic 10 Conference and played their home games at the Chaifetz Arena.

They advanced to the semifinals of the A-10 women's tournament, where they lost to Duquesne.

They were invited to the Women's National Invitation Tournament, where they defeated Arkansas–Little Rock and Ball State in the first and second round before losing to WKU in the third round.

Roster [1] 2015–16 NCAA Division I women's basketball rankings