The 2015–16 UEFA Women's Champions League knockout phase began on 7 October 2015 and concluded on 26 May 2016 with the final at Mapei Stadium – Città del Tricolore in Reggio Emilia, Italy, which decided the champions of the 2015–16 UEFA Women's Champions League.
The schedule of the competition was as follows (all draws were held at the UEFA headquarters in Nyon, Switzerland).
The team that scored more goals on aggregate over the two legs advanced to the next round.
If the aggregate score was level, the away goals rule was applied, i.e. the team that scored more goals away from home over the two legs advanced.
If away goals were also equal, then 30 minutes of extra time was played.
The away goals rule was again applied after extra time, i.e. if there were goals scored during extra time and the aggregate score was still level, the visiting team advanced by virtue of more away goals scored.
If no goals were scored during extra time, the tie was decided by penalty shoot-out.
In the final, which was played as a single match, if scores were level at the end of normal time, extra time was played, followed by penalty shoot-out if scores remained tied.
The mechanism of the draws for each round was as follows: Below are the 32 teams which participated in the knockout phase (with their 2015 UEFA club coefficients, which took into account their performance in European competitions from 2010–11 to 2014–15 plus 33% of their association coefficient from the same time span).
The draws for the quarter-finals and semi-finals were held on 27 November 2015.
The final was played on 26 May 2016 at the Mapei Stadium – Città del Tricolore in Reggio Emilia, Italy.