Contested over 301 laps on the 1.058 mile (1.703 km) speedway, it was the 19th race of the 2015 NASCAR Sprint Cup Series season.
Brad Keselowski finished second while Kevin Harvick, Joey Logano and Dale Earnhardt Jr. rounded out the top five.
Carl Edwards won the pole for the race and led 19 laps on his way to a seventh-place finish.
The 5-hour Energy 301 was carried by NBC Sports on the cable/satellite NBCSN network for the American television audience.
New Hampshire Motor Speedway is a 1.058-mile (1.703 km) oval speedway located in Loudon, New Hampshire which has hosted NASCAR racing annually since the early 1990s, as well as an IndyCar weekend and the oldest motorcycle race in North America, the Loudon Classic.
Nicknamed "The Magic Mile", the speedway is often converted into a 1.6-mile (2.6 km) road course, which includes much of the oval.
The track was originally the site of Bryar Motorsports Park before being purchased and redeveloped by Bob Bahre.
Kevin Harvick entered New Hampshire with a 68-point lead over Jimmie Johnson and Joey Logano.
The 2015 5-hour Energy 301 marked the first NASCAR Sprint Cup race after the passing of Formula One driver Jules Bianchi on 18 July 2015, who had crashed at the Japanese Grand Prix and remained in a coma for the preceding nine months.
Several drivers and team owners paid tribute to Bianchi, many of them in form of messages written on helmets and cars.
32 Go FAS Racing Ford, Derek White attempted to make his first career Sprint Cup Series start in the No.
"[16] "We hope we’ll keep this speed on race day," said Connecticut native Joey Logano after qualifying second.
We changed a lot of things and lit it up a little bit"[16] "It's not been a good day for us," said three-time New Hampshire winner Jeff Gordon after qualifying 23rd.
But that’s why we have guys that back us up.”[19] “Hopefully all this hard work and stuff we’re going through will pay off tomorrow," said Gordon, who will start 23rd.
But hopefully this will all pay off for us tomorrow.”[20] Carl Edwards was the fastest in the final practice session with a time of 28.614 and a speed of 133.110 mph (214.220 km/h).
Joey Logano, Denny Hamlin, Kyle Busch and Jimmie Johnson rounded out the pit cycle.
Matt Kenseth was tagged for speeding on pit road and was forced to serve a drive-through penalty.
Ryan Blaney was running ninth when he made an unscheduled stop for a loose right-rear tire on lap 130.
Adding insult to injury, he was tagged for speeding entering pit road and was forced to serve a drive-through penalty.
Kurt Busch started a wave of green flag stops pitting from fifth on lap 171.
Brad Keselowski pitted from the lead on lap 179 and handed it to teammate Joey Logano.
Jimmie Johnson was tagged for speeding on pit road and was forced to serve a drive-through penalty.
Clint Bowyer made contact with the turn 2 wall and cut down his right-rear tire with 93 laps to go.
He bobbled exiting turn 4 with two to go and Kyle Busch drove off to his third win of the season after Alex Bowman brought out the seventh caution of the race on the final lap.
Guys will go back and see what's wrong.”[27] Following the race, Michael Annett and Matt DiBenedetto were transported to the infield care center after showing signs of heat exhaustion and in need of fluids.
Rick Allen, Jeff Burton – the all-time wins leader at New Hampshire Motor Speedway with four victories – and Steve Letarte had the call in the booth for the race.
Dave Burns, Mike Massaro, Marty Snider and Kelli Stavast handled pit road for the television side.
Brad Gillie, Brett McMillan, Jim Noble and Steve Richards worked pit road for the radio side.