A total of 16 teams competed in the knockout stage to decide the champions of the 2015 AFC Cup.
The away goals rule (for two-legged ties), extra time (away goals would not apply in extra time) and penalty shoot-out were used to decide the winner if necessary.
The draw for the quarter-finals was held on 18 June 2015, 15:00 UTC+8, at the Grand Millennium Hotel in Kuala Lumpur, Malaysia.
[7] As a result, both Al-Qadsia and Al-Kuwait were no longer eligible to compete in the AFC Cup.
The second legs of both semi-finals were cancelled, and Johor Darul Ta'zim and Istiklol advanced to the final by walkover.