The 2015 Charleston Southern Buccaneers football team represented Charleston Southern University as a member of the Big South Conference during the 2015 NCAA Division I FCS football season.
Led by third-year head coach Jamey Chadwell, the Buccaneers compiled an overall record of 10–3 with a mark of 6–0 in conference play, winning the Big South title.
Charleston Southern earned the conference's automatic bid to the NCAA Division I Football Championship playoffs.
After a first-round bye, the Buccaneers defeated The Citadel in the second round before losing to the eventual national runner-up, Jacksonville State, in the quarterfinals.
Charleston Southern played home games at Buccaneer Field in Charleston, South Carolina.