[2] Since UANL are from Mexico, they had to host the first leg regardless of seeding (Regulations Article 3.7b: "El Torneo deberá indefectiblemente finalizar en un país perteneciente al continente sudamericano.

[7] At the break, River manager Marcelo Gallardo made an attacking double substitution, withdrawing Rodrigo Mora and Tabaré Viúdez for Gonzalo Martínez and Nicolás Bertolo, but was also suspended after shouting at the fourth official.

At 8' Lucas Alario committed an illegal strong entry against the ankle of Guido Pizarro, foul that media later considered that deserved red card.

At 46' Ramiro Funes Mori committed another illegal strong entry, this time against Rafael Sóbis, foul that media also later considered that deserved red card.

When Carlos Sánchez went down in the penalty area, he scored the resulting spot kick, shooting to the left of the goalkeeper to double the team's lead.

Four minutes later, a corner kick from the right was headed by Ramiro Funes Mori through the legs of the goalkeeper to secure a 3–0 victory, River's first Copa Libertadores for 19 years.