In international competitions, Tigres won a CONCACAF Champions League title in 2020 (finishing as runners-up three times), and was the 2015 Copa Libertadores Finals runner-up to River Plate.

In the 1973–74 season, José "Ché" Gómez guided the team to the title and promotion to the Primera División de México, now Liga MX.

[2][3][4] Under the command of Uruguayan coach Carlos Miloc and players such as Tomás Boy and Gerónimo Barbadillo, for the 1977–78 season Tigres aimed to the league championship.

In 1996, Tigres hired the Chilean international forward Claudio Núñez and after several years of ups and downs the team won their second domestic cup defeating Atlas by 2–1 but were relegated to Primera División A, now Ascenso MX, because of negative results of past seasons.

Under the command of the Brazilian coach Ricardo Ferretti, Tigres finished the Verano 2001 season in the fourth place with 27 points and secured postseason.

On the Apertura 2003, now under the command of Argentine coach Nery Pumpido (with a team that Ferretti build), Tigres finished the tournament as leader now with 38 points.

In the Clausura 2004, Argentine striker Andrés Silvera finished the tournament as one of the top goal scorers,[10] but Tigres ended in 12th place and missed the play-offs.

[10] In the quarter-finals, under the command of the iconic Osvaldo Batocletti, Tigres played the historical "Aztecazo", a way to describe a difficult victory over América or the Mexico national team in their venue, the Estadio Azteca.

With the adherence of Argentine winger Damián Álvarez, Brazilian attacking midfielder Danilinho and Chilean striker Héctor Mancilla to captain Lucas Lobos, the offensive line of Tigres became the so-called "Cuatro Fantásticos" ("Fantastic Four").

On 11 December 2011, with goals from Héctor Mancilla, Danilinho and Alan Pulido, Tigres won 3–1 at the Estadio Universitario, becoming champion for the third time after 29 years.

[11] Tigres brought in experienced Argentine striker Emanuel Villa while Danilinho returned from his loan to Brazil, giving the team a highly offensive power for the Clausura 2013 season.

Tigres hired Colombian winger Hernán Darío Burban, defender Jorge Iván Estrada and Argentine striker Emanuel Herrera for the Clausura 2014 tournament, but finished the season in 14th place, missing the playoffs.

Tigres hired Brazilian forward Rafael Sóbis and finished the Clausura 2015 regular season in first place with 29 points, earning a ticket to playoffs.

In the postseason, with goals from Gignac and Damián Álvarez, Tigres won the first quarter-final leg 2–1 against Jaguares de Chiapas at the Estadio Universitario.

With only one minute left of extra time remaining, however, UNAM scored the 4–1 goal and equalized the aggregate scoreline at 4–4, sending the match to a penalty shoot-out.

On 10 July 2016, Tigres won the 2016 edition of the Campeón de Campeones Cup against Pachuca FC by 1–0 at the StubHub Center in Carson, California.

Tigres lost the second leg by 2–1 at the Estadio Omnilife for an aggregate of 4–3, in a controversial match where press and audience claimed that referee Luis Enrique Santander, who had refereed all of the home games of Guadalajara in play-offs, did not penalize a foul of Guadalajara's defender Jair Pereira over Ismael Sosa inside the penalty area minutes before the end of the match.

[22] For the Apertura 2017 season, Tigres acquired Ecuadorian forward Enner Valencia, Brazilian midfielder Rafael Carioca and French defender Timothée Kolodziejczak.

[23] On 16 July 2017, Tigres beat Guadalajara by 1–0 at the StubHub Center in Carson, California, becoming the back-to-back Champion of the Campeón de Campeones Cup by winning the 2017 and 2016 editions.

[25] For the Apertura 2018 season, Tigres rehired Guido Pizarro and on 15 July 2018, defeated Santos by 4–0 at the StubHub Center in Carson, California, becoming Champion of the Campeón de Campeones Cup for the third time in a row.

On May 20, 2021, after finishing the Clausura 2021 season in tenth place and losing against Atlas the reclassification, Tigres hired coach Miguel Herrera,[26] ending an eleven-year successful era under command of Ricardo Ferretti.

For the Apertura 2021 season, Tigres hired the international French and 2018 World Cup champion Florian Thauvin but lost against Club León in semifinals.

A talented goalkeeper, he was part of the squad that was relegated to Primera División "A", now Liga Expansión in March 24, 1996 and returned to the top tier after a year.

With goal of Sebastián Córdova, Tigres defeated Puebla FC in the "repechaje" (reclassification) for the liguilla (playoffs) by 1-0, setting the team against Toluca in quarterfinals.

By finishing the regular season of the Apertura 2014 as second place with 31 units, Tigres advanced to Copa Libertadores 2015 as Mexico 1 to play in Group 6 against River Plate, San José and Juan Aurich.

[28] In the second leg at Estadio Universitario on 26 May, Tigres won by 2–0 with goals of Rafael Sóbis and José Rivas for an aggregate of 2-1 reaching semifinals against S.C. Internacional.

[28][27] As the runners-up of the Apertura 2014, Tigres qualified to the 2015–16 CONCACAF Champions League, playing their first match of the tournament on 18 August, only thirteen days after the second leg of the final of the 2015 Copa Libertadores.

After getting relegated and made all of their games Local-PPV in 1996, fans continued their unwavering support during the year it took the club to achieve promotion back to Liga MX.

Its fan base expands to other states such as Coahuila, Durango, San Luis Potosí, Tamaulipas, Veracruz and (like many other Liga MX teams) in the US, particularly Texas.

Source: Liga MX Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.