[1] The draw of the tournament was held on December 2, 2014, 21:00 UTC−3, at the CONMEBOL Convention Centre in Luque, Paraguay.
However, a first stage winner, whose identity was not known at the time of the draw, could be drawn into the same group with another team from the same association.
If tied on points, tiebreakers were applied in the following order:[1] The matches were played on February 17–19, 24–26, March 3–5, 10–12, 17–19, April 1, 7–9, 14–16, and 21–22, 2015.
Note: This was the first time the Clássico Majestoso derby matches between Corinthians and São Paulo were played in the Copa Libertadores.
Note: San Lorenzo played their home match against Corinthians behind closed doors as they were punished for crowd disturbances in the second leg of the 2014 Copa Libertadores Finals.