The 2015 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Ohio Valley Conference (OVC) during the 2015 NCAA Division I FCS football season.

Led by second-year head coach Kim Dameron, the Eastern Illinois compiled an overall record of 7–5 overall with a mark of 7–1 in conference play, placing second in the OVC.

The Panthers received an at-large bid to the NCAA Division I Football Championship playoffs, where they lost in the first round to Northern Iowa.

The team played home games at O'Brien Field in Charleston, Illinois.