The climate of Nashville and the wear of hosting a game nearly every weekend often required the field to be resodded in the area between the hashes in November, and the stadium had amongst the highest lower body injuries of any in the NFL during the 2018–2021 seasons.

[20] On the stadium's eastern side is the Titans Pro Shop, a retail store that sells team merchandise.

During the 1995 NFL Preseason, the Houston Oilers faced the Washington Redskins in an exhibition game at Neyland Stadium in Knoxville, Tennessee.

At the game, Oilers owner Bud Adams met Nashville Mayor Phil Bredesen and began discussing the possibility of moving the team to Middle Tennessee[citation needed] due to Adams' discontent with the team's lease at the Astrodome and unwillingness of the City of Houston to build a new football-only stadium.

The city and team decided to locate a stadium on the eastern bank of the Cumberland River across from downtown Nashville, in what had been a declining industrial/warehousing area.

In a special referendum on May 7, 1996, voters in Metropolitan Nashville/Davidson County voted to approve partial funding of the proposed stadium.

On May 3, 2010, the stadium's playing surface was filled with 6 feet (1.8 m) of water due to the heavy rains and flooding from the Cumberland River.

During the 2018 season, two 20th anniversary logos were put in each of the end zones to help celebrate the Titans' 20th year in Nashville.

In February 2022, the Titans paused ongoing renovations to the stadium, citing the rising costs and the structure,[27] to explore the possibility of replacing the facility in the near future.

[29] On July 3, 2024, human remains of an unhoused man who disappeared a couple days prior were located inside a tent were found in a section of the stadium parking lot that is located near the Cumberland River, foul play has not suspected in the incident and the official cause of death has not been determined yet.

[32][33] As part of the sponsor agreement, a 2016 Nissan Titan pickup truck was placed next to the stadium scoreboard.

[34] The Tennessee Titans began playing at Nissan Stadium in 1999, winning their first 13 games before losing to the Baltimore Ravens on November 12, 2000.

The "Music City Miracle" (as it has come to be known) was a last-minute trick play on a kickoff return that resulted in a touchdown and catapulted the Titans past the Buffalo Bills to the Divisional Playoffs.

[39][40] On April 1, 2009, the U.S. men's national team played a World Cup qualifier beating Trinidad and Tobago, 3–0.

[41][42] The U.S. men returned March 29, 2011 falling to Paraguay in a friendly before a record crowd of 29,059 – the largest to attend a soccer game in the state of Tennessee.