It was also the fourth season under the trio of head coach Chuck Pagano, general manager Ryan Grigson and quarterback Andrew Luck.

After a week 8 loss to the Carolina Panthers, the Colts fired offensive coordinator Pep Hamilton and elevated associate head coach Rob Chudzinski to replace him.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.

The Titans had a chance to tie the game after pulling within 35–33, but the 2-point attempt failed, and the Colts held on for the win.

Due to an injured shoulder, Andrew Luck missed the first game of his career, and was replaced by 40-year-old veteran Matt Hasselbeck, who avoided any turnovers and led the Colts to a 16–13 win in overtime.

Jacksonville kicker Jason Myers would miss 3 game-winning field goal attempts at the end of the fourth quarter and one in overtime.

Despite a Hail Mary being thrown at the end of the first half, the Colts still managed to hold on for the win.

In the Super Bowl rematch between the two teams, the Saints started the first half, dominating the Colts 20–0, which stunned Indy's home crowd.

The Colts looked for answers in the second half, but Andrew Luck struggled to find open receivers and he was intercepted twice.

The Colts traveled to Charlotte to take on Cam Newton and his undefeated Carolina Panthers, looking to hang their first loss on them.

He ended up missing the rest of the season, putting more pressure on veteran backup Matt Hasselbeck, who was 2–0 in 2 starts due to Luck's previous injury.

The Colts would trail 21–7 late in the third quarter, but they would fight back to tie the game at 21 after D'Qwell Jackson returned an interception at the Atlanta 6-yard line for a touchdown.

With the loss, the Colts fell to 6–7 and lost to a divisional opponent for the first time since 2012, snapping their NFL record 16-game winning streak in division play.